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This is a brutally effective means of ensuring that a target under heavy focused fire cannot be saved by the enemy Monk(s). Previously cast protections will be removed, allowing your attacks to have full effect, and the enemy healers will have to work twice as hard to repair the damage dealt.
Lingering Curse is most effective in teams that focus their attacks on a single target. It is also very useful to put on the enemy Ghostly Hero in altar maps such as the Hall of Heroes, when killing the enemy Hero holding the Altar is of utmost importance.
Lingering Curse does not affect life stealing skills.
And of course, be sure to cover the hex for more effective use.