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Unlike most Order skills, this is not an enchantment. As such, the duration cannot be extended with weapons of Enchanting.
The 2% health loss is not considered sacrifice, and will not trigger skills such as Dark Aura.
The 2% health loss is not considered damage either, so there is no way to prevent it.
If using Vampiric Horrors, the extra damage they inflict is also added to the health you gain. This can help offset the health loss incurred with each attack.