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If the condition can't be transferred to the target (either because the target is immune to that particular condition, or because it dies before Plague Sending finishes casting), it will still be removed from the caster.
Can be used well with skills that cause conditions on yourself to negate their drawback by sending those to foes. See Self condition inflict skills quick reference for an overview.
Anomaly! This skill's description is redundant, because all conditions are negative.