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Full: For 5...17...20 seconds, while you are casting spells, foes cannot target you with spells. When Spell Shield ends, all your skills are disabled for 10...6...5 seconds.
Concise: (5...17...20 seconds.) While casting spells, you cannot be the target of spells. End effect: your skills are disabled (10...6...5 seconds).
At Divine Favor 16, using Blessed Aura and a +20% enchanting mod, Spell Shield can be kept up indefinitely so the skills are never disabled. Alternatively, Glyph of Swiftness and a +20% enchanting mod at 16 Divine Favor can be used.
An excellent way to prevent spell-based interrupts.